Protein-Sparing Modified Fast (PSMF) Weight Loss Studies

Here are some of the scientific studies concerning Protein Sparing Modified Fasts (PSMF) and high protein diets.

PSMF Diets

• A Palgi, J L Read, I Greenberg, M A Hoefer, B R Bistrian, and G L Blackburn Multidisciplinary treatment of obesity with a protein-sparing modified fast: results in 668 outpatients. American Journal of Public Health, October 1985
• Bistrian DR, Winterer J, Blackburn GL, Young V, Sherman M.. Effect of a protein-sparing diet and brief fast on nitrogen metabolism in mildly obese subjects, J Lab Clin Med. 1977 May;89(5):1030-5.
• Van Gaal LF, Snyders D, De Leeuw IH, Bekaert JL. Anthropometric and calorimetric evidence for the protein sparing effects of a new protein supplemented low calorie preparation. Am J Clin Nutr. 1985; 41:410-540.
• Curr Opin Endocrinol Diabetes Obes. 2008 Oct;15(5):416-21. Benefits of high-protein weight loss diets: enough evidence for practice? Brehm BJ, D’Alessio DA.
• Am J Clin Nutr. 2005 Jun;81(6):1298-306. Effect of an energy-restricted, high-protein, low-fat diet relative to a conventional high-carbohydrate, low-fat diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese women. Noakes M, Keogh JB, Foster PR, Clifton PM.
• Eur J Nutr. 2013 Feb;52(1):317-25. Comparison of the effects of weight loss from a high-protein versus standard-protein energy-restricted diet on strength and aerobic capacity in overweight and obese men. Wycherley TP, Buckley JD, Noakes M, Clifton PM, Brinkworth GD.
• Schoeller DA1, Buchholz AC. Energetics of obesity and weight control: does diet composition matter?J Am Diet Assoc. 2005 May;105(5 Suppl 1):S24-8.
• Layman DK, Boileau RA, Erickson DJ, Painter JE, Shiue H, Sather C, Christou DD. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. J Nutr. 2003 Feb;133(2):411-7.
• Halton TL, Hu FB. The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr. 2004 Oct;23(5):373-85.
• Brehm BJ, D’Alessio DA. Benefits of high-protein weight loss diets: enough evidence for practice? Curr Opin Endocrinol Diabetes Obes. 2008 Oct;15(5):416-21.
• de Luis, et.al. Effects of a high-protein/low carbohydrate versus a standard hypocaloric diet on adipocytokine levels and insulin resistance in obese patients along 9 months. Journal of Diabetes and its Complications. Volume 29, Issue 7, September–October 2015, Pages 950-954.