GNG in Fasting

From (Nutrition. 1995 Mar-Apr;11(2):149-53. Glycerol gluconeogenesis in fasting humans. Baba H1, Zhang XJ, Wolfe RR.): The contribution of glycerol to glucose production has been measured in healthy volunteers by the simultaneous primed constant infusion of 1-[13C]glycerol and 3-[3H]glucose and the determination of the rates of appearance (Ra) of glycerol, glucose, and glycerol-derived glucose. In the postabsorptive state … Continue reading “GNG in Fasting”

How Metformin Works

Researchers have unlocked more about how Metformin works (Zydrune Polianskyte-Prause, Tuomas A. Tolvanen, Sonja Lindfors, Vincent Dumont, Mervi Van, Hong Wang, Surjya N. Dash, Mika Berg, Jette-Britt Naams, Laura C. Hautala, Harry Nisen, Tuomas Mirtti, Per-Henrik Groop, Kristiina Wähälä, Jukka Tienari, and Sanna Lehtonen. Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity. The … Continue reading “How Metformin Works”

How Much Protein on Low Carb Diets?

The DRI (Dietary Reference Intake) is 0.8 grams of protein per kilogram of body weight, or 0.36 grams per pound.  This amounts to: * 56 grams per day for the average sedentary man.* 46 grams per day for the average sedentary woman. As I noted in a prior post (Overfeeding Studies) minimum protein requirements are … Continue reading “How Much Protein on Low Carb Diets?”

Glucose Needs on Low Carb Diet

We have a dietary requirement for some glucose. When we eat a Low Carbohydrate Diet we don’t get enough glucose directly from our diet. In that case our bodies will make glucose from either protein or fat either from our diet or from our body via Gluconeogenesis (GNG). This is shown in this study (A … Continue reading “Glucose Needs on Low Carb Diet”

Overfeeding Studies

There are quite a few interesting overfeeding studies. The typical format of these studies is to take subjects and first determine the caloric intake to keep them in energy balance (weight stable). The study will then increase one of the three macronutrients (fat, carbohydrate or protein) and then look at the effects. Often studied are … Continue reading “Overfeeding Studies”

Glucose Response to Protein

I wrote a post a while back comparing my blood sugar response to protein compared to a non-diabetic friend’s response (Blood Sugar Responses Compared). In that n=2 study I noted that my blood sugar goes up a bit when I consume protein but my non-diabetic associate’s blood sugar goes down. Turns out this difference has … Continue reading “Glucose Response to Protein”

Alcohol and Blood Sugar

It is widely known that alcohol lowers blood sugar, but why does it? From an interesting study (CHARLES U. LOWE, LUIS L. MOSOVICH. The Paradoxical Effect of Alcohol on Carbohydrate Metabolism in Four Patients with Liver Glycogen Disease. Pediatrics, June 1965, VOLUME 35 / ISSUE 6.). Oxidation of ethanol to acetaldehyde, the first step in … Continue reading “Alcohol and Blood Sugar”

Blood Sugar and Fasting

A while back, I noticed that my Blood Sugar peaks around the second day of extended fasting. George Cahill did the seminal work measuring blood markers during starvation (Cahill, George. Fuel Metabolism in Starvation.). Here’s an interesting chart from that study that explains the sources of glucose during starvation. This demonstrates the increase in blood … Continue reading “Blood Sugar and Fasting”

The Big Fat Hack – Day 4

Jimmy Moore is doing a big fat hack. He’s on day 4. And Jimmy is producing more drama than ketones at this point. Jimmy’s claim to have developed glucagon resistance is a curious one. Jimmy may have actually dropped his glycogen stores down to where there’s not enough glycogen to convert to glucagon when needed. Since … Continue reading “The Big Fat Hack – Day 4”