Gluconeogenesis – Later Thoughts

I’ve spend time thinking about Gluconeogenesis (GNG). That’s the process where the liver creates glucose from other substrates, including Protein. Earlier on I though Protein was the culprit and was limiting my Protein intake. I don’t believe that was the problem. I believe that the problem was that my liver was overproducing glucose because it was overly fat.

And it turns out that the liver of a diabetic is particularly good at gluconeogensis. From this paper (Diabetes. 2000 Dec; 49(12): 2063–2069. Mechanism by Which Metformin Reduces Glucose Production in Type 2 Diabetes. Ripudaman S. Hundal, Martin Krssak, Sylvie Dufour, Didier Laurent, Vincent Lebon, Visvanathan Chandramouli, Silvio E. Inzucchi, William C. Schumann, Kitt F. Petersen, Bernard R. Landau, and Gerald I. Shulman) GNG is shown to be around 2x as good as a non-diabetic.

The rate of glucose production was twice as high in the diabetic subjects as in control subjects (0.70 ± 0.05 vs. 0.36 ± 0.03 mmol · m−2 · min−1, P < 0.0001).

And later in the paper:

The rate of gluconeogenesis was three times higher in the diabetic subjects than in the control subjects (0.59 ± 0.03 vs. 0.18 ± 0.03 mmol · m−2 · min−1)



Author: Doug

I'm an Engineer who is also a science geek. I was pre-diabetic in 1996 and became a diabetic in 2003. I decided to figure out how to hack my diabetes and in 2016 found the ketogetic diet which reversed my diabetes.

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